2 1/2 pounds lean chuck or bottom round roast - (to 3)
1 1/2 cups ketchup
1/4 cup brown sugar - (packed)
1/4 cup red wine vinegar
2 tablespoons Dijon mustard
2 tablespoons Worcestershire sauce
1 teaspoon liquid smoke flavoring
1/2 teaspoon salt
1/4 teaspoon freshly-ground black pepper
1/2 teaspoon garlic powder
6 sandwich buns - (to 8)
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